THE CHEMICAL PROBES PORTAL: NORTH CAROLINA NON-PROFIT CORPORATION: WRITE REVIEW: Address: The Chemical Probes Portal, Genetic Medicine Research Building #1073, 120 Mason Farm Rd Chapel Hill, NC 27599: Registered Agent: Filing Date: February 19, 2016: File Number: 1499175: Contact Us About The Company Profile For The Chemical Probes Portal A potent, selective, and cell-active modulator of a specific protein can be invaluable for figuring out what that protein actually does. Although both pharmacological tools and labelled chemical probes have a major place in drug discovery, there are differences regarding their design and applicability. The Chemical Probes Portal is designed to change the way scientists find and use small-molecule reagents called chemical probes in biomedical research and drug discovery. The portal is designed to provide easy, free access to expert-reviewed information on chemical probes for various target proteins. Help is provided for example by the Chemical Probes Portal (Baell and Walters, 2014; Blagg and Workman, 2017), which was established in 2015 to provide a comprehensive overview of published and newly released tool compounds that are anno- tated with a simple star-rating system. The Chemical Probes Portal is designed to facilitate user searches that can be based on either the probe or the biological target of interest. Pharmacological tools are of particular importance in the chemical biology field. Chemical structures are displayed, as well as names, a radar plot showing the six Chemical Probe scores, the Chemical Probes Portal reviewers' rating, and Probe Miner ranking when available. Users can come to the portal … The main emphasis of projects submitted under this FOA should be in the discovery of cell-based chemical probes rather than chemical leads for drug or therapeutic discovery. When applying a chemical probe in a new cellular system, it is important to consider several factors. Identifying chemical probes that meet all the demands of an experimental design is not a trivial task. recommended concentrations, applications, etc.). Open Science Probes 73. All compounds submitted to the portal … The Chemical Probes Portal is an online open access catalog of annotated small molecule inhibitors, agonists and other chemical tools for biological research and preclinical drug discovery. Even worse in many cases, probe … This website uses cookies to store a small amount of information on your computer, as part of the functioning of the site. 4860. A chemical probe is a reagent that is capable of discerning the biology of an intended biological target within the context of a linked disease (Bunnage, Chekler, & Jones, 2013).A number of criteria have been proposed for chemical probes and it is generally agreed that they are small molecules capable … The Portal is backed by reviews and commentary from recognised chemical probe experts. Chemical probes are small molecules developed to selectively inhibit protein targets. The Chemical Probes Portal is a freely available, web-based resource that provides recommendations about which probes are best for a particular purpose. Illustrating the strength of this resource, searching for the ‘PARP1’ target (carried out on 8/3/2019) pointed to ten bona fide PARP inhibitors such as the genetically-targeted cancer drug olaparib Applicants interested in developing in vivo chemical probes may wish to apply using the companion R01 mechanism (PAR-17-336. The company's File Number is listed as 001266715. These recommendations are made by a panel of independent experts who make up the Scientific Advisory Board of the portal. … The Chemical Probes Portal in a nonprofit organization that seeks to increase the reproducibility of biomedical research using chemical probes through community curation and communication. Many researchers are unaware of just … Update: the chemical probes portal mentioned here has since been updated and re-launched. Nature Chemical Biology Probes 58. SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. Chemical Probes.org 243. New website – Chemical Probes Portal – has been launched to help researchers choose better quality research tools and avoid errors in biomedical research. You can sort the table by clicking the column headers. Bromodomains chemical toolbox 25. Gray Laboratory Probes 53. opnMe Portal 49. Information on candidates are typically scattered over various sources and its gathering can be very time consuming. Browse PubChem data sources by country, type of data provided or category such as chemical vendors/suppliers, government organizations, journal publishers, and more. Axon Medchem Screening Library. On the bottom, highest-ranked probes for CHEK2, OPRK1 and ABCC8. Projects seeking … Brochure - SGC Epigenetic Chemical Probes … The Chemical Probes Portal has been updated, the new site includes a lot more data about the existing probes, reviewer ratings and their comments.. A chemical probe is simply a reagent—a selective small-molecule modulator of a protein’s function—that allows the user to ask mechanistic and phenotypic questions about … To its utility as an experimental reagent ” to combat bad data research tools and avoid errors in biomedical.. Although both pharmacological tools and labelled chemical probes that meet all the demands of an experimental is! 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